\u3ci\u3eOn the Sacred Disease\u3c/i\u3e: The Historical Significance of Hippocratic Humanism, Rationality and Scientific Procedure

Although many of the Hippocratic Corpus\u27 anatomical, physiological and pathological doctrines have since been superseded, the premise of On the Sacred Disease - that disease is of a physical origin - stimulated the rise of rational, secular, and systematic medicine over magico-religious healing and the recognition of medicine as a true techne, or science. Before the time of Hippocrates, \u27pre-scientific\u27 Western medicine was predominantly magico-religious or characterized by magic-based appeals to supernatural beings. In On the Sacred Disease, however, Hippocrates attributes disease to both internal and external factors. Further holding that prognosis should be based on thorough examination, Hippocrates required highly detailed and meticulous clinical observations of his patients. After extensive studying of the work of Hippocrates, second century practitioner Galen argued in On Medical Experience that truth can be obtained only by means of reason in conjunction with experience, because expectation founded on reason alone is likely to be fruitless and misleading. As such, through its contributions to medical practicum and the scientific method, Hippocrates\u27 On the Sacred Disease remains as relevant in contemporary Westem society as it was over two millennia ago on the-Greek island of Cos

Projected temperature-related deaths in ten large U.S. metropolitan areas under different climate change scenarios.

BACKGROUND: There is an established U-shaped association between daily temperature and mortality. Temperature changes projected through the end of century are expected to lead to higher rates of heat-related mortality but also lower rates of cold-related mortality, such that the net change in temperature-related mortality will depend on location. OBJECTIVES: We quantified the change in heat-, cold-, and temperature-related mortality rates through the end of the century across 10 large US metropolitan areas. METHODS: We applied location-specific projections of future temperature from over 40 downscaled climate models to exposure-response functions relating daily temperature and mortality in 10 US metropolitan areas to estimate the change in temperature-related mortality rates in 2045-2055 and 2085-2095 compared to 1992-2002, under two greenhouse gas emissions scenarios (RCP 4.5 and 8.5). We further calculated the total number of deaths attributable to temperature in 1997, 2050, and 2090 in each metropolitan area, either assuming constant population or accounting for projected population growth. RESULTS: In each of the 10 metropolitan areas, projected future temperatures were associated with lower rates of cold-related deaths and higher rates of heat-related deaths. Under the higher-emission RCP 8.5 scenario, 8 of the 10 metropolitan areas are projected to experience a net increase in annual temperature-related deaths per million people by 2086-2095, ranging from a net increase of 627 (95% empirical confidence interval [eCI]: 239, 1018) deaths per million in Los Angeles to a net decrease of 59 (95% eCI: -485, 314) deaths per million in Boston. Applying these projected temperature-related mortality rates to projected population size underscores the large public health burden of temperature. CONCLUSIONS: Increases in the heat-related death rate are projected to outweigh decreases in the cold-related death rate in 8 out of 10 cities studied under a high emissions scenario. Adhering to a lower greenhouse gas emissions scenario has the potential to substantially reduce future temperature-related mortality